General Information

  • ID:  hor002861
  • Uniprot ID:  Q8ISH7
  • Protein name:  Feeding circuit activating peptide h
  • Gene name:  NA
  • Organism:  Aplysia californica (California sea hare)
  • Family:  NA
  • Source:  animal
  • Expression:  Expressed in pleural, pedal, abdominal, buccal and cerebral ganglia.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NLNNLGSFQVHGW
  • Length:  13(632-644)
  • Propeptide:  MTFAASFRALLCVLFCAALVHCKTRTKRYVPHSELWRILAVVDELQREQAAEQRQEDALALALRSDIAGGGGGGQLADNVRWFPETYDYGALADRDVDKRVFDSLGGYEVHGFKKRGSLDAIPQDTDASSDKRALDSLGGFQVHGWKRALDTLGGFQVHGWKRGSGAEKRQVDRLGGFQVHGWKKRALDSLGGFQVHGWKKRGTGGQMHASSPRVVPWGSRSLLADTQSGHRWKRDTELVENRQTTGQQTEVNKR
  • Signal peptide:  MTFAASFRALLCVLFCAALVHC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be important and unique components of intercellular signaling in the feeding circuitry and may contribute to the induction and persistence of food-induced arousal
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q8ISH7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002861_AF2.pdbhor002861_ESM.pdb

Physical Information

Mass: 169985 Formula: C67H96N20O19
Absent amino acids: ACDEIKMPRTY Common amino acids: N
pI: 7.55 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 5
Hydrophobicity: -39.23 Boman Index: -1245
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 82.31
Instability Index: 494.62 Extinction Coefficient cystines: 5500
Absorbance 280nm: 458.33

Literature

  • PubMed ID:  12196603
  • Title:  Identification and characterization of the feeding circuit-activating peptides, a novel neuropeptide family of Aplysia.